MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.

Kalogirou, C; Linxweiler, J; Schmucker, P; Snaebjornsson, M T; Schmitz, W; Wach, S; Krebs, M; Hartmann, E; Puhr, M; Müller, A; Spahn, M; Seitz, A K; Frank, T; Marouf, H; Büchel, G; Eckstein, M; Kübler, H; Eilers, M; Saar, M; Junker, K; Röhrig, F; Kneitz, B; Rosenfeldt, M T; Schulze, A

Kalogirou, C; Linxweiler, J; Schmucker, P; Snaebjornsson, M T; Schmitz, W; Wach, S; Krebs, M; Hartmann, E; Puhr, M; Müller, A; Spahn, M; Seitz, A K; Frank, T; Marouf, H; Büchel, G; Eckstein, M; Kübler, H; Eilers, M; Saar, M; Junker, K; Röhrig, F; Kneitz, B; Rosenfeldt, M T; Schulze, A.

Afiliação

Kalogirou C; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
Linxweiler J; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
Schmucker P; Department of Urology, Saarland University, Homburg/Saar, Germany.
Snaebjornsson MT; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
Schmitz W; German Cancer Research Center, Division of Tumor Metabolism and Microenvironment, Heidelberg, Germany.
Wach S; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
Krebs M; Department of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Hartmann E; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
Puhr M; Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany.
Müller A; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Spahn M; Clinic for Diagnostic and Interventional Radiology, Saarland University, Homburg/Saar, Germany.
Seitz AK; Center for Urology, Hirslanden Private Hospital Group, Zurich, Switzerland.
Frank T; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
Marouf H; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
Büchel G; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
Eckstein M; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
Kübler H; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany.
Eilers M; Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Saar M; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.
Junker K; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
Röhrig F; Department of Urology, Saarland University, Homburg/Saar, Germany.
Kneitz B; Department of Urology, Saarland University, Homburg/Saar, Germany.
Rosenfeldt MT; Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.
Schulze A; Department of Urology and Paediatric Urology, University Hospital Würzburg, Würzburg, Germany.

Nat Commun ; 12(1): 5066, 2021 08 20.

Article em En | MEDLINE | ID: mdl-34417456

Assuntos

Colesterol; Regulação para Baixo; Regulação Neoplásica da Expressão Gênica; MicroRNAs; Neoplasias da Próstata; Esqualeno Mono-Oxigenase; Idoso; Idoso de 80 Anos ou mais; Animais; Humanos; Masculino; Camundongos; Pessoa de Meia-Idade; Sequência de Bases; Linhagem Celular Tumoral; Proliferação de Células/genética; Sobrevivência Celular; Colesterol/biossíntese; Estudos de Coortes; Simulação por Computador; Modelos Animais de Doenças; Regulação para Baixo/genética; Resistencia a Medicamentos Antineoplásicos/genética; Camundongos SCID; MicroRNAs/genética; MicroRNAs/metabolismo; Invasividade Neoplásica; Metástase Neoplásica; Estadiamento de Neoplasias; Antígeno Prostático Específico/metabolismo; Neoplasias da Próstata/tratamento farmacológico; Neoplasias da Próstata/genética; Neoplasias da Próstata/patologia; Neoplasias de Próstata Resistentes à Castração/genética; Neoplasias de Próstata Resistentes à Castração/patologia; Receptores Androgênicos/metabolismo; Esqualeno Mono-Oxigenase/antagonistas & inibidores; Esqualeno Mono-Oxigenase/genética; Esqualeno Mono-Oxigenase/metabolismo; Terbinafina/farmacologia; Ativação Transcricional/genética

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Prostata Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Regulação para Baixo / Regulação Neoplásica da Expressão Gênica / Colesterol / MicroRNAs / Esqualeno Mono-Oxigenase Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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