Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity.

Li, Yingzhong; Su, Zhijun; Zhao, Weiyu; Zhang, Xinfu; Momin, Noor; Zhang, Chengxiang; Wittrup, K Dane; Dong, Yizhou; Irvine, Darrell J; Weiss, Ron

Li, Yingzhong; Su, Zhijun; Zhao, Weiyu; Zhang, Xinfu; Momin, Noor; Zhang, Chengxiang; Wittrup, K Dane; Dong, Yizhou; Irvine, Darrell J; Weiss, Ron.

Afiliação

Li Y; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Su Z; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zhao W; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zhang X; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Momin N; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Zhang C; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wittrup KD; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Dong Y; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Irvine DJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Weiss R; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Nat Cancer ; 1(9): 882-893, 2020 09.

Article em En | MEDLINE | ID: mdl-34447945

Assuntos

Nanopartículas; Neoplasias; Animais; Imunoterapia/métodos; Interleucina-12/genética; Lipossomos; Camundongos; Neoplasias/genética; RNA; Microambiente Tumoral

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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