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The Norwegian childhood cancer biobank.
Hermansen, Johanne U; Wojcik, Dorota M; Robinson, Nina; Pahnke, Jens; Haugland, Hans Kristian; Jamtøy, Ann Helen; Flaegstad, Trond; Halvorsen, Hanne; Lund, Bendik; Baumbusch, Lars O; Munthe-Kaas, Monica C.
Afiliação
  • Hermansen JU; Department of Oncology, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Wojcik DM; Department of Pediatric Research, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Robinson N; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
  • Pahnke J; Department of Oncology, Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Haugland HK; Department of Pathology, Section for Neuropathology, Oslo University Hospital, Oslo, Norway.
  • Jamtøy AH; Department of Pathology, Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Flaegstad T; Department of Pharmacology, Medical Faculty, University of Latvia, Riga, Latvia.
  • Halvorsen H; Department of Pathology, Haukeland University Hospital, Bergen, Norway.
  • Lund B; Department of Pathology, St. Olavs Hospital, Trondheim, Norway.
  • Baumbusch LO; Department of Pediatrics, University Hospital of North-Norway, Tromsø, Norway.
  • Munthe-Kaas MC; Faculty of Health Science, The Arctic University of Norway, Tromsø, Norway.
Cancer Rep (Hoboken) ; 5(8): e1555, 2022 08.
Article em En | MEDLINE | ID: mdl-34541832
BACKGROUND: The rapidly expanding era of "omics" research is highly dependent on the availability of quality-proven biological material, especially for rare conditions such as pediatric malignancies. Professional biobanks provide such material, focusing on standardized collection and handling procedures, distinctive quality measurements, traceability of storage conditions, and accessibility. For pediatric malignancies, traditional tumor biobanking is challenging due to the rareness and limited amount of tissue and blood samples. The higher molecular heterogeneity, lower mutation rates, and unique genomic landscapes, however, renders biobanking of this tissue even more crucial. AIM: The aim of this study was to test and establish methods for a prospective and centralized biobank for infants, children, and adolescents up to 18 years of age diagnosed with cancer in Norway. METHODS: Obtain judicial and ethical approvals and administration through a consortium, steering committee, and advisory board. Develop pipelines including SOPs for all aspects in the biobank process, including collection, processing and storing of samples and data, as well of quality controlling, safeguarding, distributing, and transport. RESULTS: The childhood cancer biobanking started at Oslo University Hospital in March 2017 and was from 2019 run as a national Norwegian Childhood Cancer Biobank. Informed consent and biological samples are collected regionally and stored centrally. Approximately 12 000 samples from 510 patients and have been included by January 1, 2021, representing a 96% consent and participation rate among our newly diagnosed patients. CONCLUSION: A well-functioning nationwide collection and centralized biobank with standardized procedures and national storage for pediatric malignancies has been established with a high acceptance among families.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Bancos de Espécimes Biológicos / Neoplasias Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Humans País/Região como assunto: Europa Idioma: En Revista: Cancer Rep (Hoboken) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Noruega

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Bancos de Espécimes Biológicos / Neoplasias Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Humans País/Região como assunto: Europa Idioma: En Revista: Cancer Rep (Hoboken) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Noruega