Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR.

Liu, Xiaojia; Yin, Mingxiao; Dong, Jingwen; Mao, Genxiang; Min, Wenjian; Kuang, Zean; Yang, Peng; Liu, Lu; Zhang, Na; Deng, Hongbin

Liu, Xiaojia; Yin, Mingxiao; Dong, Jingwen; Mao, Genxiang; Min, Wenjian; Kuang, Zean; Yang, Peng; Liu, Lu; Zhang, Na; Deng, Hongbin.

Afiliação

Liu X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yin M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Dong J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Mao G; Zhejiang Provincial Key Lab of Geriatrics, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China.
Min W; State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Kuang Z; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yang P; State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Liu L; Qingdao Women and Children's Hospital, Qingdao University, Qingdao 266034, China.
Zhang N; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Deng H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Acta Pharm Sin B ; 11(10): 3134-3149, 2021 Oct.

Article em En | MEDLINE | ID: mdl-34745852

Palavras-chave

4EBP1, eIF4E-binding protein 1; Baf, bafilomycin A1; CETSA, cellular thermal shift assay; CHX, cycloheximide; CQ, chloroquine; IB, immunoblotting; ICB, immune checkpoint blockade; IHC, immunohistochemistry; Immune checkpoint blockade; LLC, Lewis lung carcinoma; Lysosome; MDSCs, myeloid-derived suppressor cells; NAG, ß-N-acetylglucosaminidase; NSCLC, non-small cell lung cancer; PD-1, programmed cell death-1; PD-L1; PD-L1, programmed cell death ligand- 1; SPR, surface plasmon resonance; TBM-1, tubeimoside-1; TFEB, nuclear transcriptional factor EB; TILs, tumor-infiltrating lymphocytes; Transcription factor EB; Tregs, regulatory T-lymphocytes; mTOR; mTOR, mammalian target of rapamycin; p70S6K, phosphorylation of p70 S6 kinase; qRT-PCR, quantitative real-time polymerase chain reaction

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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