Continuous infusion of lidocaine in pediatric colonoscopy: A randomized double-blind placebo-controlled study.
Saudi J Gastroenterol
; 28(1): 54-59, 2022.
Article
em En
| MEDLINE
| ID: mdl-34806658
ABSTRACT
BACKGROUND:
Propofol is commonly used for providing procedural sedation during pediatric colonoscopy. Intravenous (i.v.) lidocaine can mitigate visceral pain and reduce propofol requirements during surgery. The aim of this study is to investigate the effect of i.v. lidocaine on perioperative propofol and sufentanil dose, pulse oxygen saturation, postoperative pain score, and recovery time during pediatric colonoscopy.METHODS:
We designed a randomized, double-blind, placebo-controlled study and enrolled 40 children aged from 3 to 10 years who underwent colonoscopy. After titration of propofol to achieve unconsciousness, the patients were given i.v. lidocaine (1.5 mg/kg later 2 mg/kg/hour) or the same volume of saline. Sedation was standardized and combined propofol with sufentanil. The primary outcome variables were intraoperative propofol and sufentanil requirements, and the number of oxygen desaturation episodes. Secondary outcome variables were recovery time after colonoscopy and post-colonoscopy pain.RESULTS:
Lidocaine infusion resulted in a significant reduction in propofol requirements (median (quartile) 1.8 (1.5-2.0) vs. 3.0 (2.8-3.3) mg/kg respectively; P < 0.001) and sufentanil requirements (median (quartile) 0.06 (0.05-0.08) vs. 0.1 (0.1-0.1) µg/kg respectively; P < 0.001). The number of subjects who experienced oxygen desaturation below 95% in the lidocaine group was also significantly less than that in the control group 1 vs. 6 (P = 0.04). The mean (SD) recovery time was significantly shorter in the lidocaine group (19.2 (2.6) vs. 13.3 (2.6) min respectively; P < 0.001). There was no significant difference in post-colonoscopy pain.CONCLUSION:
Continuous infusion of lidocaine resulted in reduction of propofol and sufentanil requirements, recovery time, and risk of hypoxemia during pediatric colonoscopy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Propofol
/
Lidocaína
Tipo de estudo:
Clinical_trials
Limite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Saudi J Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China