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Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation.
Longchamps, R J; Yang, S Y; Castellani, C A; Shi, W; Lane, J; Grove, M L; Bartz, T M; Sarnowski, C; Liu, C; Burrows, K; Guyatt, A L; Gaunt, T R; Kacprowski, T; Yang, J; De Jager, P L; Yu, L; Bergman, A; Xia, R; Fornage, M; Feitosa, M F; Wojczynski, M K; Kraja, A T; Province, M A; Amin, N; Rivadeneira, F; Tiemeier, H; Uitterlinden, A G; Broer, L; Van Meurs, J B J; Van Duijn, C M; Raffield, L M; Lange, L; Rich, S S; Lemaitre, R N; Goodarzi, M O; Sitlani, C M; Mak, A C Y; Bennett, D A; Rodriguez, S; Murabito, J M; Lunetta, K L; Sotoodehnia, N; Atzmon, G; Ye, K; Barzilai, N; Brody, J A; Psaty, B M; Taylor, K D; Rotter, J I; Boerwinkle, E.
Afiliação
  • Longchamps RJ; Department of Genetic Medicine, McKusick-Nathans Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Yang SY; Department of Genetic Medicine, McKusick-Nathans Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Castellani CA; Department of Genetic Medicine, McKusick-Nathans Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Shi W; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
  • Lane J; Department of Genetic Medicine, McKusick-Nathans Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Grove ML; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Bartz TM; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Sarnowski C; Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA.
  • Liu C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Burrows K; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Guyatt AL; MRC Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
  • Gaunt TR; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
  • Kacprowski T; Department of Health Sciences, University of Leicester, University Road, Leicester, UK.
  • Yang J; MRC Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
  • De Jager PL; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
  • Yu L; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
  • Bergman A; Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School, Brunswick, Germany.
  • Xia R; Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  • Fornage M; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Feitosa MF; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Wojczynski MK; Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  • Kraja AT; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Province MA; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Amin N; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Rivadeneira F; Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, USA.
  • Tiemeier H; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, USA.
  • Uitterlinden AG; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, USA.
  • Broer L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, USA.
  • Van Meurs JBJ; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, USA.
  • Van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Raffield LM; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Lange L; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Rich SS; Department of Social and Behavioral Science, Harvard T.H. School of Public Health, Boston, USA.
  • Lemaitre RN; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Goodarzi MO; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Sitlani CM; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Mak ACY; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Bennett DA; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Rodriguez S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Murabito JM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Lunetta KL; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Sotoodehnia N; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
  • Atzmon G; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Ye K; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Barzilai N; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Brody JA; Cardiovascular Research Institute and Institute for Human Genetics, University of California, San Francisco, CA, USA.
  • Psaty BM; Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  • Taylor KD; MRC Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
  • Rotter JI; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
  • Boerwinkle E; Boston University School of Medicine, Boston University, Boston, MA, USA.
Hum Genet ; 141(1): 127-146, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34859289
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Megacariócitos / Ativação Plaquetária / Polimorfismo de Nucleotídeo Único / Variações do Número de Cópias de DNA / Mitocôndrias Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Genet Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Megacariócitos / Ativação Plaquetária / Polimorfismo de Nucleotídeo Único / Variações do Número de Cópias de DNA / Mitocôndrias Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Genet Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos