Your browser doesn't support javascript.
loading
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Gomaa, Hesham A M; Shaker, Mohamed E; Alzarea, Sami I; Hendawy, O M; Mohamed, Fatma A M; Gouda, Ahmed M; Ali, Asmaa T; Morcoss, Martha M; Abdelrahman, Mostafa H; Trembleau, Laurent; Youssif, Bahaa G M.
Afiliação
  • Gomaa HAM; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia. Electronic address: hasoliman@ju.edu.sa.
  • Shaker ME; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
  • Alzarea SI; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
  • Hendawy OM; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia; Department of Clinical Pharmacology, Faculty of Medicine, Beni-Suef University, Egypt.
  • Mohamed FAM; Clinical Laboratory Science Department, College of Applied Medical Sciences, Jouf University, Aljouf 72341, Saudi Arabia; Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.
  • Gouda AM; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Ali AT; Biochemistry Department, Faculty of Pharmacy, Nahda University, 62513 Beni-Suef, Egypt.
  • Morcoss MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, 62513 Beni-Suef, Egypt.
  • Abdelrahman MH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
  • Trembleau L; School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, United Kingdom. Electronic address: l.trembleau@abdn.ac.uk.
  • Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: bahaa.youssif@pharm.aun.edu.eg.
Bioorg Chem ; 120: 105616, 2022 03.
Article em En | MEDLINE | ID: mdl-35078049
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas B-raf / Antineoplásicos Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas B-raf / Antineoplásicos Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article