All-Trans Retinoic Acid-Preconditioned Mesenchymal Stem Cells Improve Motor Function and Alleviate Tissue Damage After Spinal Cord Injury by Inhibition of HMGB1/NF-&#954;B/NLRP3 Pathway Through Autophagy Activation.

Gholaminejhad, Morteza; Jameie, Seyed Behnamedin; Abdi, Mahdad; Abolhassani, Farid; Mohammed, Ibrahim; Hassanzadeh, Gholamreza

All-Trans Retinoic Acid-Preconditioned Mesenchymal Stem Cells Improve Motor Function and Alleviate Tissue Damage After Spinal Cord Injury by Inhibition of HMGB1/NF-κB/NLRP3 Pathway Through Autophagy Activation.

Gholaminejhad, Morteza; Jameie, Seyed Behnamedin; Abdi, Mahdad; Abolhassani, Farid; Mohammed, Ibrahim; Hassanzadeh, Gholamreza.

Afiliação

Gholaminejhad M; Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Jameie SB; Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abdi M; Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abolhassani F; Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Mohammed I; Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Hassanzadeh G; Department of Histopathology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria.

J Mol Neurosci ; 72(5): 947-962, 2022 May.

Article em En | MEDLINE | ID: mdl-35147911

Assuntos

Proteína HMGB1; Células-Tronco Mesenquimais; Traumatismos da Medula Espinal; Animais; Autofagia; Proteína Beclina-1/genética; Proteína HMGB1/genética; Humanos; Inflamação; NF-kappa B; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Ratos; Traumatismos da Medula Espinal/tratamento farmacológico; Tretinoína/farmacologia; Tretinoína/uso terapêutico; Fator de Necrose Tumoral alfa

Palavras-chave

All-trans retinoic acid; Autophagy; Mesenchymal stem cells; NLRP3 inflammasome; Nuclear factor-kappa B; Spinal cord injury

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tratamento Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Proteína HMGB1 / Células-Tronco Mesenquimais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Mol Neurosci Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irã

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