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Iridium(III)-Cp*-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol analogues as hypoxia active, GSH-resistant cancer cytoselective and mitochondria-targeting cancer stem cell therapeutic agents.
Kar, Binoy; Shanavas, Shanooja; Nagendra, Apoorva H; Das, Utpal; Roy, Nilmadhab; Pete, Sudhindra; Sharma S, Ajay; De, Sourav; Kumar S K, Ashok; Vardhan, Seshu; Sahoo, Suban K; Panda, Debashis; Shenoy, Sudheer; Bose, Bipasha; Paira, Priyankar.
Afiliação
  • Kar B; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
  • Shanavas S; Department Stem Cells and Regenerative Medicine Centre, Institution Yenepoya Research Centre, Yenepoya University, University Road, Derlakatte, Mangalore 575018, Karnataka, India. bipasha.bose@gmail.com.
  • Nagendra AH; Department Stem Cells and Regenerative Medicine Centre, Institution Yenepoya Research Centre, Yenepoya University, University Road, Derlakatte, Mangalore 575018, Karnataka, India. bipasha.bose@gmail.com.
  • Das U; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
  • Roy N; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
  • Pete S; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
  • Sharma S A; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
  • De S; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
  • Kumar S K A; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
  • Vardhan S; Department of Applied Chemistry, S. V. National Institute of Technology (SVNIT), Ichchanath, Surat, Gujrat-395007, India. suban_sahoo@rediffmail.com.
  • Sahoo SK; Department of Applied Chemistry, S. V. National Institute of Technology (SVNIT), Ichchanath, Surat, Gujrat-395007, India. suban_sahoo@rediffmail.com.
  • Panda D; Department of Basic Sciences and Humanities, Rajiv Gandhi Institute of Petroleum Technology, An Institution of National Importance, Jais, Amethi-229304, Uttar Pradesh, India. dpanda@rgipt.ac.in.
  • Shenoy S; Department Stem Cells and Regenerative Medicine Centre, Institution Yenepoya Research Centre, Yenepoya University, University Road, Derlakatte, Mangalore 575018, Karnataka, India. bipasha.bose@gmail.com.
  • Bose B; Department Stem Cells and Regenerative Medicine Centre, Institution Yenepoya Research Centre, Yenepoya University, University Road, Derlakatte, Mangalore 575018, Karnataka, India. bipasha.bose@gmail.com.
  • Paira P; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India. priyankar.paira@vit.ac.in.
Dalton Trans ; 51(14): 5494-5514, 2022 Apr 05.
Article em En | MEDLINE | ID: mdl-35293923
ABSTRACT
Herein, we have introduced a series of iridium(III)-Cp*-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes via a convenient synthetic methodology, which act as hypoxia active and glutathione-resistant anticancer metallotherapeutics. The [IrIII(Cp*)(L5)(Cl)](PF6) (IrL5) complex exhibited the best cytoselectivity, GSH resistance and hypoxia effectivity in HeLa and Caco-2 cells among the synthesized complexes. IrL5 also exhibited highly cytotoxic effects on the HCT-116 CSC cell line. This complex was localized in the mitochondria and subsequent mitochondrial dysfunction was observed via MMP alteration and ROS generation on colorectal cancer stem cells. Cell cycle analysis also established the potential of this complex in mediating G2/M phase cell cycle arrest.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Complexos de Coordenação / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Complexos de Coordenação / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia