Discovery of small-molecule inhibitors of RUVBL1/2 ATPase.

Zhang, Gang; Wang, Feng; Li, Shan; Cheng, Kai-Wen; Zhu, Yingying; Huo, Ran; Abdukirim, Elyar; Kang, Guifeng; Chou, Tsui-Fen

Zhang, Gang; Wang, Feng; Li, Shan; Cheng, Kai-Wen; Zhu, Yingying; Huo, Ran; Abdukirim, Elyar; Kang, Guifeng; Chou, Tsui-Fen.

Afiliação

Zhang G; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States. Electronic address: gzhang2@caltech.edu.
Wang F; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
Li S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
Cheng KW; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States.
Zhu Y; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Huo R; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Abdukirim E; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Kang G; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China. Electronic address: guifengkang@ccmu.edu.cn.
Chou TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States; Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, United States. Electronic address: tfchou@caltech.edu.

Bioorg Med Chem ; 62: 116726, 2022 05 15.

Article em En | MEDLINE | ID: mdl-35364523

Assuntos

Adenosina Trifosfatases; Antineoplásicos; ATPases Associadas a Diversas Atividades Celulares/metabolismo; Adenosina Trifosfatases/metabolismo; Antineoplásicos/química; Antineoplásicos/farmacologia; Proteínas de Transporte/metabolismo; DNA Helicases; Ensaios de Seleção de Medicamentos Antitumorais; Proteômica; Relação Estrutura-Atividade

Palavras-chave

AAA ATPase; Docking; Organic synthesis; Pontin; Proteomics; Pyrazolo[1,5-a]pyrimidine-3-carboxamide; RUVBL1; RUVBL2, Reptin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Adenosina Trifosfatases / Antineoplásicos Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google