Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types.

Budczies, Jan; Kluck, Klaus; Beck, Susanne; Ourailidis, Iordanis; Allgäuer, Michael; Menzel, Michael; Kazdal, Daniel; Perkhofer, Lukas; Kleger, Alexander; Schirmacher, Peter; Seufferlein, Thomas; Stenzinger, Albrecht

Budczies, Jan; Kluck, Klaus; Beck, Susanne; Ourailidis, Iordanis; Allgäuer, Michael; Menzel, Michael; Kazdal, Daniel; Perkhofer, Lukas; Kleger, Alexander; Schirmacher, Peter; Seufferlein, Thomas; Stenzinger, Albrecht.

Afiliação

Budczies J; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Kluck K; German Cancer Consortium (DKTK), Heidelberg, Germany.
Beck S; Centers for Personalized Medicine (ZPM), Heidelberg and Ulm Partner Sites, Germany.
Ourailidis I; German Center for Lung Research (DZL), Heidelberg, Germany.
Allgäuer M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Menzel M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Kazdal D; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Perkhofer L; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Kleger A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Schirmacher P; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Seufferlein T; German Center for Lung Research (DZL), Heidelberg, Germany.
Stenzinger A; Centers for Personalized Medicine (ZPM), Heidelberg and Ulm Partner Sites, Germany.

J Pathol Clin Res ; 8(4): 371-382, 2022 07.

Article em En | MEDLINE | ID: mdl-35384413

Assuntos

Instabilidade de Microssatélites; Neoplasias Ovarianas; Biomarcadores Tumorais/genética; Carcinoma Epitelial do Ovário; Feminino; Recombinação Homóloga; Humanos; Neoplasias Ovarianas/genética; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Inibidores de Poli(ADP-Ribose) Polimerases/uso terapêutico; Microambiente Tumoral/genética

Palavras-chave

HRD; MSI; PARP inhibitors; T-cell inflamed gene expression profile; homologous recombination deficiency; immune cell populations; microsatellite instability; tumor mutational burden

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Instabilidade de Microssatélites Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: J Pathol Clin Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

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