GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.
Blood Sci
; 3(2): 40-47, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-35402833
ABSTRACT
GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown. Here, we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process. Gsdme -/- mice revealed no difference in the steady state of blood system while Gsdme -/- HSCs exhibited compromised reconstitution capacity due to increased apoptosis. Briefly, this study reveals that GSDME modulates HSC function by coordinating pyroptosis and apoptosis.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Idioma:
En
Revista:
Blood Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China