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Immunolabelling of Acetylated Histones 3 and 4 and Histone Deacetylases 1, 2 and 6 in Canine Soft Tissue Sarcomas.
Sena, Bruna V; Horta, Rodrigo S; Senhorello, Igor L S; Matiz, Oscar R S; Canavari, Isabela C; Souza, Larissa M; Ferreira, Marília G P A; Sueiro, Felipe A R; Costa, Mirela T; de Nardi, Andrigo B.
Afiliação
  • Sena BV; Department of Veterinary Medicine and Surgery, Veterinay School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Horta RS; Department of Veterinary Medicine and Surgery, Veterinay School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: rodrigohorta@ufmg.br.
  • Senhorello ILS; Department of Veterinary Medicine, Universidade Vila Velha, Vila Velha, ES, Brazil.
  • Matiz ORS; Autonomous Veterinarian, Life - Oncologia Veterinária, Bogotá, Colombia.
  • Canavari IC; Department of Clinical and Veterinary Surgery, College of Agricultural and Veterinary Sciences, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Jaboticabal, SP, Brazil.
  • Souza LM; Autonomous Veterinarian, Vila Velha, ES, Brazil.
  • Ferreira MGPA; Veterinary Hospital, Universidade Federal do Vale do São Francisco, HU-Univasf, Petrolina, PE, Brazil.
  • Sueiro FAR; VETPAT Pathology and Molecular Biology Laboratory, Campinas, SP, Brazil.
  • Costa MT; Department of Clinical and Veterinary Surgery, College of Agricultural and Veterinary Sciences, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Jaboticabal, SP, Brazil.
  • de Nardi AB; Department of Clinical and Veterinary Surgery, College of Agricultural and Veterinary Sciences, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Jaboticabal, SP, Brazil.
J Comp Pathol ; 193: 51-58, 2022 May.
Article em En | MEDLINE | ID: mdl-35487622
ABSTRACT
The objective of this study was to investigate the immunolabelling of acetylated histones and histone desacetylase (HDAC) enzymes in canine soft tissue sarcomas (STSs) and to correlate them with histological and clinical features in order to identify possible prognostic and therapeutic targets in these neoplasms. Fifteen canine STS samples were evaluated and were submitted to immunohistochemistry for acetylated histones 3 (H3) and 4 (H4) and deacetylating enzymes (HDAC1, HDAC2 and HDAC6). Intense immunolabelling of H4 was seen in comparison with H3. A strong positive correlation was observed between the H3 intensity score and the number of mitotic figures (P = 0.004, r = 0.7). Intense immunolabelling of HDAC1 was found in comparison to the expression of HDAC2 and HDAC6 in the evaluated STSs. This finding suggests that HDAC1 may be a potential target for HDAC inhibitors in STSs in dogs.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Sarcoma / Doenças do Cão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Comp Pathol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Sarcoma / Doenças do Cão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Comp Pathol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil