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Multi-pathway inducing ferroptosis by MnO2-based nanodrugs for targeted cancer therapy.
Fan, Shuhua; Yang, Qiangqiang; Song, Qianna; Hong, Min; Liu, Xiaoyan; Chen, Haobin; Wang, Juan; Li, Chuan; Cheng, Shuang.
Afiliação
  • Fan S; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Yang Q; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Song Q; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Hong M; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Liu X; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Chen H; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Wang J; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Li C; School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, Shandong, China. hongmin@lcu.edu.cn.
  • Cheng S; School of Agriculture, Liaocheng University, Liaocheng, 252059, Shandong, China. chengshuang@lcu.edu.cn.
Chem Commun (Camb) ; 58(45): 6486-6489, 2022 Jun 01.
Article em En | MEDLINE | ID: mdl-35551311
A multifunctional nanodrug (Tf-DHA-ASO-MnO2) based on manganese dioxide nanosheets was constructed by triple-dressing with transferrin, dihydroartemisinin, and antisense oligonucleotide sequences. Tf-DHA-ASO-MnO2 shows an effective targeted cancer therapy ability through the ferroptosis caused by the production of excessive lipid peroxides resulting from the combined effect of glutathione exhaustion, reactive oxygen species generation and down-regulation of glutathione peroxidase 4.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Nanopartículas / Ferroptose / Neoplasias Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Nanopartículas / Ferroptose / Neoplasias Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China