Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress-related AMPK/FoxO1 signaling.

Richter, Robert P; Ashtekar, Amit R; Zheng, Lei; Pretorius, Danielle; Kaushlendra, Tripathi; Sanderson, Ralph D; Gaggar, Amit; Richter, Jillian R

Richter, Robert P; Ashtekar, Amit R; Zheng, Lei; Pretorius, Danielle; Kaushlendra, Tripathi; Sanderson, Ralph D; Gaggar, Amit; Richter, Jillian R.

Afiliação

Richter RP; Division of Pediatric Critical Care Medicine, Department of Pediatrics.
Ashtekar AR; Program in Protease and Matrix Biology.
Zheng L; Center for Injury Science.
Pretorius D; Division of Pediatric Critical Care Medicine, Department of Pediatrics.
Kaushlendra T; Center for Injury Science.
Sanderson RD; Division of Acute Care Surgery, Department of Surgery.
Gaggar A; Division of Pediatric Critical Care Medicine, Department of Pediatrics.
Richter JR; Center for Injury Science.

JCI Insight ; 7(15)2022 08 08.

Article em En | MEDLINE | ID: mdl-35763350

Assuntos

Angiopoietina-2; Sepse; Proteínas Quinases Ativadas por AMP/metabolismo; Angiopoietina-2/metabolismo; Animais; Biomarcadores/metabolismo; Criança; Células Endoteliais/metabolismo; Proteína Forkhead Box O1/metabolismo; Glicocálix/metabolismo; Heparitina Sulfato/metabolismo; Humanos; Camundongos; Transdução de Sinais

Palavras-chave

Endothelial cells; Glycobiology; Proteases; Vascular Biology

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Sepse / Angiopoietina-2 Tipo de estudo: Prognostic_studies Limite: Animals / Child / Humans Idioma: En Revista: JCI Insight Ano de publicação: 2022 Tipo de documento: Article

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