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Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
Heinrich, Timo; Peterson, Carl; Schneider, Richard; Garg, Sakshi; Schwarz, Daniel; Gunera, Jakub; Seshire, Anita; Kötzner, Lisa; Schlesiger, Sarah; Musil, Djordje; Schilke, Heike; Doerfel, Benjamin; Diehl, Patrizia; Böpple, Pia; Lemos, Ana R; Sousa, Pedro M F; Freire, Filipe; Bandeiras, Tiago M; Carswell, Emma; Pearson, Nicholas; Sirohi, Sameer; Hooker, Mollie; Trivier, Elisabeth; Broome, Rebecca; Balsiger, Alexander; Crowden, Abigail; Dillon, Christian; Wienke, Dirk.
Afiliação
  • Heinrich T; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Peterson C; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Schneider R; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Garg S; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Schwarz D; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Gunera J; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Seshire A; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Kötzner L; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Schlesiger S; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Musil D; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Schilke H; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Doerfel B; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Diehl P; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Böpple P; Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
  • Lemos AR; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras 2781-901, Portugal.
  • Sousa PMF; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras 2781-901, Portugal.
  • Freire F; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras 2781-901, Portugal.
  • Bandeiras TM; iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras 2781-901, Portugal.
  • Carswell E; Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K.
  • Pearson N; Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K.
  • Sirohi S; Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K.
  • Hooker M; Cancer Research Horizons, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, U.K.
  • Trivier E; MSD, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, U.K.
  • Broome R; Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Balsiger A; Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Crowden A; Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Dillon C; Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Wienke D; Cancer Research Horizons, 4NW, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
J Med Chem ; 65(13): 9206-9229, 2022 07 14.
Article em En | MEDLINE | ID: mdl-35763499
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Neoplasias Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Neoplasias Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha