<i>In vitro</i> and <i>in vivo</i> characterization of erythrosin B and derivatives against Zika virus.

Li, Zhong; Xu, Jimin; Lang, Yuekun; Wu, Xiangmeng; Hu, Saiyang; Samrat, Subodh Kumar; Tharappel, Anil M; Kuo, Lili; Butler, David; Song, Yongcheng; Zhang, Qing-Yu; Zhou, Jia; Li, Hongmin

In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus.

Li, Zhong; Xu, Jimin; Lang, Yuekun; Wu, Xiangmeng; Hu, Saiyang; Samrat, Subodh Kumar; Tharappel, Anil M; Kuo, Lili; Butler, David; Song, Yongcheng; Zhang, Qing-Yu; Zhou, Jia; Li, Hongmin.

Afiliação

Li Z; Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Xu J; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Lang Y; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Wu X; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Hu S; Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Samrat SK; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Tharappel AM; Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Kuo L; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Butler D; Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85721-0207, USA.
Song Y; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Zhang QY; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Zhou J; The Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
Li H; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Acta Pharm Sin B ; 12(4): 1662-1670, 2022 Apr.

Article em En | MEDLINE | ID: mdl-35847519

Palavras-chave

AUC, area under he curve; Antiviral; DENV, dengue virus; DMSO, dimethyl sulfoxide; Dengue virus; EB, erythrosin B; Erythrosin B; FDA, US Food and Drug Administration; FRET, fluorescence resonance energy transfer; Flavivirus; NS, non-structural protein; ORF, open reading frame; PFU, plaque-forming unit; PK, pharmacokinetic; PP, polyprotein precursor; Protease inhibitor; SAR, structure−activity relationship; SLC, split luciferase complementation; UTR, untranslated region; WHO, World Health Organization; ZIKV, Zika virus; Zika virus; aa, amino acid; dpi, day post infection; ip, intraperitoneal

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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