Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.
Small Sci
; 2(6): 2270012, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35942318
ABSTRACT
Oridonin Inhibits SARS-CoV-2 Oridonin, a natural product extracted from Rabdosia rubescens, possesses a wide range of pharmacological properties, including anti-inflammatory, anti-cancer, anti-microbial, neuroprotection, immunoregulation, etc. In article number 2100124, Baisen Zhong, Litao Sun, and co-workers demonstrate that Oridonin targets the SARS-CoV-2 3CL protease by covalently binding to cysteine145 in its active pocket to exert an anti-SARS-CoV-2 effect, which provides a novel candidate for the treatment of COVID-19.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Idioma:
En
Revista:
Small Sci
Ano de publicação:
2022
Tipo de documento:
Article