The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumors.
Cell Cycle
; 22(1): 38-56, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-35946607
ABSTRACT
The cGAS/STING signaling pathway is an important part of the cytoplasmic DNA sensor, which can trigger a type I interferon response to microbial infection when pathogenic DNA is detected. However, continuous inhibition of cGAS/STING signaling by viral infection may be an important cause of tumorigenesis. At the same time, recent studies have shown that although the cGAS/STING signaling pathway also plays a core role in anti-tumor immunity and cell senescence, the inflammatory response induced by cGAS/STING signaling will also promote tumorigenesis in different backgrounds. Here, we discuss the role of cGAS/STING in the context of infection, senescence, and tumors, especially with respect to progression, to facilitate a better understanding of the mechanism of the cGAS/STING pathway.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Interferon Tipo I
Limite:
Humans
Idioma:
En
Revista:
Cell Cycle
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China