A LIGHT-HVEM/LTßR axis contributes to the fibrosis of intrauterine adhesion.
J Reprod Immunol
; 153: 103693, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35987137
ABSTRACT
Intrauterine adhesion (IUA) is a fibrotic disease, with complex and multifactorial process, causing menstrual disorders, pregnancy loss or infertility. LIGHT (also named TNFSF14), mainly expressed by immune cells, has been reported to be associated with tissue fibrosis. However, the features of immunocyte subsets, the expression and roles of LIGHT and its receptor HVEM (herpes virus entry mediator) and LTßR (lymphotoxin beta receptor) in IUA remain largely unknown. Compared with the control group, we observed increased ratios of CD45+ cells, neutrophils, T cells, macrophages and decreased natural killer cells proportion, and high LIGHT expression on CD4+ T cells and macrophages in IUA endometrium. Further analysis showed there was a positive correlation between upregulated profibrotic factors (e.g., É-smooth muscle actin, transforming growth factor ß1) and HVEM in IUA endometrial tissue. More importantly, recombinant human LIGHT protein directly up-regulated the expression of HVEM, LTßR, profibrotic and proinflammatory factors expression in human endometrial stromal cells. These findings reveal abnormal changes of immune cell subsets proportion and the overexpression of LIGHT-HVEM/LTßR axis in IUA endometrium, should contribute to inflammation and fibrosis formation of IUA.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Doenças Uterinas
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Membro 14 da Superfamília de Ligantes de Fatores de Necrose Tumoral
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Receptor beta de Linfotoxina
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Membro 14 de Receptores do Fator de Necrose Tumoral
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Reprod Immunol
Ano de publicação:
2022
Tipo de documento:
Article