Citrullination is linked to reduced Ca<sup>2+</sup> sensitivity in hearts of a murine model of rheumatoid arthritis.

Pironti, Gianluigi; Gastaldello, Stefano; Rassier, Dilson E; Lanner, Johanna T; Carlström, Mattias; Lund, Lars H; Westerblad, Håkan; Yamada, Takashi; Andersson, Daniel C

Citrullination is linked to reduced Ca²⁺ sensitivity in hearts of a murine model of rheumatoid arthritis.

Pironti, Gianluigi; Gastaldello, Stefano; Rassier, Dilson E; Lanner, Johanna T; Carlström, Mattias; Lund, Lars H; Westerblad, Håkan; Yamada, Takashi; Andersson, Daniel C.

Afiliação

Pironti G; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Gastaldello S; Department of Medicine, Cardiology Research Unit, Karolinska Institutet, Stockholm, Sweden.
Rassier DE; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Lanner JT; Department of Kinesiology and Physical Education, McGill University, Montreal, Canada.
Carlström M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Lund LH; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Westerblad H; Department of Medicine, Cardiology Research Unit, Karolinska Institutet, Stockholm, Sweden.
Yamada T; Heart, Vascular and Neurology Theme, Cardiology Unit, Karolinska University Hospital, Stockholm, Sweden.
Andersson DC; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Acta Physiol (Oxf) ; 236(3): e13869, 2022 11.

Article em En | MEDLINE | ID: mdl-36002394

Assuntos

Artrite Experimental; Artrite Reumatoide; Insuficiência Cardíaca; Animais; Camundongos; Citrulinação; Citrulina/metabolismo; Desiminases de Arginina em Proteínas/genética; Desiminases de Arginina em Proteínas/metabolismo; Fator de Necrose Tumoral alfa; Modelos Animais de Doenças; Actinas; Hidrolases/metabolismo; Artrite Reumatoide/metabolismo; Artrite Experimental/metabolismo; Arginina/farmacologia

Palavras-chave

Ca2+ sensitivity; PAD; citrullination; heart failure; rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Artrite Experimental / Artrite Reumatoide / Insuficiência Cardíaca Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Acta Physiol (Oxf) Assunto da revista: FISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia

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