CAR T Cells Contend with Myeloma in the Bone Marrow Microenvironment.
Blood Cancer Discov
; 3(6): 478-480, 2022 11 02.
Article
em En
| MEDLINE
| ID: mdl-36026510
ABSTRACT
In this issue of Blood Cancer Discovery, Dhodapkar and colleagues find that myeloid, dendritic, and endogenous T-cell populations in the bone marrow microenvironment are associated with progression-free survival (PFS) in multiple myeloma patients responding to B-cell maturation antigen-targeted CAR T cells. Immunosuppressive myeloid cells are associated with short PFS, but a diverse T-cell receptor repertoire and more dendritic cells are associated with a longer PFS, suggesting a potential role for epitope spreading. See related article by Dhodapkar et al., p. 490 (6).
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Tipos_de_cancer
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Outros_tipos
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Tratamento
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Transplante_de_medula_ossea
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Medula Óssea
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Receptores de Antígenos Quiméricos
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Mieloma Múltiplo
Limite:
Humans
Idioma:
En
Revista:
Blood Cancer Discov
Ano de publicação:
2022
Tipo de documento:
Article