Unravelling the pharmacokinetics of aflatoxin B1: <i>In vitro</i> determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes.

Lootens, Orphélie; De Boevre, Marthe; Gasthuys, Elke; Van Bocxlaer, Jan; Vermeulen, An; De Saeger, Sarah

Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes.

Lootens, Orphélie; De Boevre, Marthe; Gasthuys, Elke; Van Bocxlaer, Jan; Vermeulen, An; De Saeger, Sarah.

Afiliação

Lootens O; Department of Bioanalysis, Centre of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium.
De Boevre M; Department of Bioanalysis, Laboratory of Medical Biochemistry and Clinical Analysis, Ghent University, Ghent, Belgium.
Gasthuys E; MYTOX-SOUTH®, International Thematic Network, Ghent, Belgium.
Van Bocxlaer J; Department of Bioanalysis, Centre of Excellence in Mycotoxicology and Public Health, Ghent University, Ghent, Belgium.
Vermeulen A; MYTOX-SOUTH®, International Thematic Network, Ghent, Belgium.
De Saeger S; Department of Bioanalysis, Laboratory of Medical Biochemistry and Clinical Analysis, Ghent University, Ghent, Belgium.

Front Microbiol ; 13: 988083, 2022.

Article em En | MEDLINE | ID: mdl-36110298

Palavras-chave

CYP450 enzymes; LCMS/MS; MichaelisMenten constant; aflatoxin B1; human liver microsomes; in vitro; mycotoxins; pharmacokinetic

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Idioma: En Revista: Front Microbiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bélgica

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