Disease recurrence in patients with Crohn's disease after biologic therapy or surgery: a meta-analysis.
Int J Colorectal Dis
; 37(10): 2185-2195, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-36149447
ABSTRACT
BACKGROUND:
Relapse is a problem in patients with Crohn's disease (CD) after medical therapy (including biologics) and after surgery to treat acute inflammation. It is unclear whether the recurrence rate over time is higher after surgical therapy than after continuous drug treatment.AIM:
We sought to compare clinical relapse rates and the need for re-interventions (resection or therapeutic endoscopic intervention) in patients with CD.METHODS:
A meta-analysis was performed according to PRISMA guidelines.RESULTS:
The need for one of the three re-interventions (surgery, biologics or both) increased over time. The recurrence rates in patients after ileocecal resection were lower than the rates under biologic therapy. The odds ratio for clinical recurrence under biologics versus after surgical treatment was 2.50 (95% confidence interval [CI] 1.53-4.08, p-value < 0.001). The odds ratio for surgical recurrence under biologics versus after surgery was 3.60 (95% CI 1.06-12.3, p-value 0.041).CONCLUSION:
These findings support surgical resection as a treatment option in patients with CD with limited disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Cirurgia_oncologica
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Doença de Crohn
Tipo de estudo:
Guideline
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Int J Colorectal Dis
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha