Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun <i>N</i>-terminal kinase inhibitors.

Schepetkin, Igor A; Kovrizhina, Anastasia R; Stankevich, Ksenia S; Khlebnikov, Andrei I; Kirpotina, Liliya N; Quinn, Mark T; Cook, Matthew J

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors.

Schepetkin, Igor A; Kovrizhina, Anastasia R; Stankevich, Ksenia S; Khlebnikov, Andrei I; Kirpotina, Liliya N; Quinn, Mark T; Cook, Matthew J.

Afiliação

Schepetkin IA; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Kovrizhina AR; Kizhner Research Center, Tomsk Polytechnic University, Tomsk, Russia.
Stankevich KS; Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, United States.
Khlebnikov AI; Kizhner Research Center, Tomsk Polytechnic University, Tomsk, Russia.
Kirpotina LN; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Quinn MT; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Cook MJ; Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, United States.

Front Pharmacol ; 13: 958687, 2022.

Article em En | MEDLINE | ID: mdl-36172181

Palavras-chave

11H-indeno[1,2-b]quinoxalin-11-one; anti-inflammatory; c-Jun N-terminal kinase; interleukin-6; nuclear factor-κB; oxime; tryptanthrin

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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