Decreased drug absorption in a patient with Behçet's syndrome.
Clin Chem
; 33(9): 1679-81, 1987 Sep.
Article
em En
| MEDLINE
| ID: mdl-3621584
ABSTRACT
Observing a lack of response to orally administered drugs in a patient with Behçet's disease, we studied the absorption of amitriptyline, diazepam, carbamazepine, phenytoin, and acetaminophen in this patient after single and (or) multiple dose administrations. The relative oral/intramuscular bioavailability of amitriptyline was only 13%, and the steady-state concentrations of this drug on four consecutive days were acutely subtherapeutic (i.e., 3.6, 3.7, 3.9, and 3.7 micrograms/L). The concentrations of diazepam, phenytoin, and acetaminophen in plasma were nonmeasurable. Examination of the gastrointestinal tract by endoscopy and by light and electronic microscopy of a biopsy section revealed inflammatory and vascular changes in the duodenum. In the absence of clinical evidence for malabsorption syndrome, we believe that the decreased drug absorption observed in this patient was caused by inflammatory changes associated with Behçet's syndrome.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Behçet
/
Amitriptilina
/
Enteropatias
/
Síndromes de Malabsorção
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Clin Chem
Assunto da revista:
QUIMICA CLINICA
Ano de publicação:
1987
Tipo de documento:
Article