Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay.

Abdellattif, Magda H; Elkamhawy, Ahmed; Hagar, Mohamed; Hadda, Taibi Ben; Shehab, Wesam S; Mansy, Wael; Belal, Amany; Arief, M M H; Hussien, Mostafa A

Abdellattif, Magda H; Elkamhawy, Ahmed; Hagar, Mohamed; Hadda, Taibi Ben; Shehab, Wesam S; Mansy, Wael; Belal, Amany; Arief, M M H; Hussien, Mostafa A.

Afiliação

Abdellattif MH; Department of Chemistry, College of Science, Taif University, Taif, Saudi Arabia.
Elkamhawy A; College of Pharmacy, Dongguk University-Seoul, Goyang, South Korea.
Hagar M; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Hadda TB; Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Shehab WS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Mansy W; Laboratory of Applied Chemistry and Environment, Faculty of Sciences, Mohammed Premier University, Oujda, Morocco.
Belal A; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Arief MMH; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Hussien MA; Department of Pharmaceutical Chemistry, College of Pharmacy Taif University, Taif, Saudi Arabia.

Front Pharmacol ; 13: 958379, 2022.

Article em En | MEDLINE | ID: mdl-36267293

Palavras-chave

DFT; MD; POM analyses; docking; pharmacophore sites; saccharinyl hydrazide

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Arábia Saudita

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