Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish.

Sudhakaran, Gokul; Rajesh, Ravi; Murugan, Raghul; Velayutham, Manikandan; Guru, Ajay; Boopathi, Seenivasan; Muthupandian, Saravanan; Gopinath, Pushparathinam; Arockiaraj, Jesu

Sudhakaran, Gokul; Rajesh, Ravi; Murugan, Raghul; Velayutham, Manikandan; Guru, Ajay; Boopathi, Seenivasan; Muthupandian, Saravanan; Gopinath, Pushparathinam; Arockiaraj, Jesu.

Afiliação

Sudhakaran G; Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Chennai, India.
Rajesh R; Department of Chemistry, College of Engineering and Technology, SRM Institute of Science and Technology, Chennai, India.
Murugan R; Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Chennai, India.
Velayutham M; Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Chennai, India.
Guru A; Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, SIMATS, Chennai, India.
Boopathi S; Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Chennai, India.
Muthupandian S; AMR and Nanomedicine Lab, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
Gopinath P; Department of Chemistry, College of Engineering and Technology, SRM Institute of Science and Technology, Chennai, India.
Arockiaraj J; Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Chennai, India.

Phytother Res ; 37(4): 1449-1461, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36450691

Assuntos

Síndrome do Ovário Policístico; Feminino; Humanos; Animais; Cricetinae; Síndrome do Ovário Policístico/patologia; Cricetulus; Peixe-Zebra/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Antioxidantes/metabolismo; Células CHO; Simulação de Acoplamento Molecular; Transdução de Sinais; Testosterona; Estresse Oxidativo; Fatores de Troca do Nucleotídeo Guanina/genética; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Proteínas Adaptadoras de Sinalização de Receptores de Domínio de Morte/genética; Proteínas Adaptadoras de Sinalização de Receptores de Domínio de Morte/metabolismo

Palavras-chave

apoptosis; nimbin; polycystic ovarian syndrome; testosterone; zebrafish

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico Limite: Animals / Female / Humans Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

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