Establishment of MDR1-knockout human enteroids for pharmaceutical application.

Inui, Tatsuya; Nomoto, Ryuga; Yokota, Jumpei; Yamashita, Tomoki; Okada, Kentaro; Kishimoto, Wataru; Nakase, Hiroshi; Mizuguchi, Hiroyuki

Inui, Tatsuya; Nomoto, Ryuga; Yokota, Jumpei; Yamashita, Tomoki; Okada, Kentaro; Kishimoto, Wataru; Nakase, Hiroshi; Mizuguchi, Hiroyuki.

Afiliação

Inui T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
Nomoto R; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
Yokota J; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan.
Yamashita T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, 565
Okada K; Laboratory of Biochemistry and Molecular Biology, School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan.
Kishimoto W; Department of Pharmacokinetics and Nonclinical Safety, Nippon Boehringer Ingelheim Co, Ltd, Kobe, Hyogo, 650-0047, Japan.
Nakase H; Department of Gastroenterology and Hepatology, School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, 565

Drug Metab Pharmacokinet ; 48: 100476, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36521426

Assuntos

Citocromo P-450 CYP3A; Verapamil; Humanos; Transporte Biológico; Células CACO-2; Citocromo P-450 CYP3A/metabolismo

Palavras-chave

Gastrointestinal cytochrome P450; Gene editing/CRISPR; Intestinal transport

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Verapamil / Citocromo P-450 CYP3A Limite: Humans Idioma: En Revista: Drug Metab Pharmacokinet Assunto da revista: FARMACOLOGIA / METABOLISMO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google