Positive Results from the Fecal Immunochemical Test Can Be Related to Dementia: A Nationwide Population-Based Study in South Korea.
J Alzheimers Dis
; 91(4): 1515-1525, 2023.
Article
em En
| MEDLINE
| ID: mdl-36641669
ABSTRACT
BACKGROUND:
The fecal immunochemical test (FIT) is widely used in screening for colorectal cancer (CRC), but FIT results can be positive for diseases other than CRC.OBJECTIVE:
We investigated the association between positive results of FIT and the incidence of dementia using a nationwide database.METHODS:
FIT-positive participants were collected from a database provided by the Korean National Health Insurance Service.RESULTS:
The incidence of all kinds of dementia was higher in FIT-positive than FIT-negative subjects (pâ<â0.0001). FIT-positive participants had a higher risk of Alzheimer's disease (AD) (pâ<â0.0001) and vascular dementia (pâ=â0.0002), compared to participants with FIT negativity. The risk of all kinds of dementia or AD in FIT-positive participants was higher in younger (ageâ<â65 years) than older participants (pâ<â0.0001 for all kinds of dementia; pâ=â0.0002 for AD).CONCLUSION:
FIT positivity was correlated with an increased risk of dementia, especially in participants under 65 years of age. The study suggests that clinicians can consider dementia when FIT-positive participants fail to show any malignancies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Colon_e_reto
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Demência
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Aged
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article