A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection.

Burm, Rani; Van Houtte, Freya; Verhoye, Lieven; Mesalam, Ahmed Atef; Ciesek, Sandra; Roingeard, Philippe; Wedemeyer, Heiner; Leroux-Roels, Geert; Meuleman, Philip

Burm, Rani; Van Houtte, Freya; Verhoye, Lieven; Mesalam, Ahmed Atef; Ciesek, Sandra; Roingeard, Philippe; Wedemeyer, Heiner; Leroux-Roels, Geert; Meuleman, Philip.

Afiliação

Burm R; Laboratory of Liver Infectious Diseases (LLID), Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Van Houtte F; Laboratory of Liver Infectious Diseases (LLID), Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Verhoye L; Laboratory of Liver Infectious Diseases (LLID), Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Mesalam AA; Laboratory of Liver Infectious Diseases (LLID), Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Ciesek S; Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), Dokki, Cairo 12622, Egypt.
Roingeard P; Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany.
Wedemeyer H; German Center for Infection Research, DZIF, External Partner Site, Frankfurt am Main, Germany.
Leroux-Roels G; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor Stern Kai 7, Frankfurt am Main, Germany.
Meuleman P; INSERM U966, Université François Rabelais and CHRU de Tours, Tours, France.

JHEP Rep ; 5(3): 100646, 2023 Mar.

Article em En | MEDLINE | ID: mdl-36748051

Palavras-chave

HBsAg, hepatitis B surface antigen; IC50, half maximal inhibitory concentration; IP, intraperitoneally; LLOQ, lower limit of quantification; LOD, limit of detection; NTCP, sodium taurocholate co-transporting polypeptide; Viral hepatitis; hepatitis B; hepatitis B surface antigen; hepatitis D; hu-mAb, human monoclonal antibody; human monoclonal antibody; human-liver chimeric mouse model; neutralization; prevention

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Idioma: En Revista: JHEP Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Bélgica

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