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Exogenous Thymosin Beta 4 Suppresses IPF-Lung Cancer in Mice: Possibly Associated with Its Inhibitory Effect on the JAK2/STAT3 Signaling Pathway.
Yu, Rui; Gao, Dandi; Bao, Jiali; Sun, Ronghao; Cui, Mengqi; Mao, Yunyun; Li, Kai; Hu, Enbo; Zhai, Yanfang; Liu, Yanhong; Gao, Yuemei; Xiao, Ting; Zhou, Honggang; Yang, Cheng; Xu, Junjie.
Afiliação
  • Yu R; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Gao D; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Bao J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Sun R; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Cui M; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Mao Y; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Li K; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Hu E; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Zhai Y; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Liu Y; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Gao Y; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Xiao T; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Zhou H; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Yang C; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  • Xu J; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Int J Mol Sci ; 24(4)2023 Feb 14.
Article em En | MEDLINE | ID: mdl-36835236
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown etiology. At present, the mortality rate of the deadly disease is still very high, while the existing treatments only delay the progression of the disease and improve the quality of life of patients. Lung cancer (LC) is the most fatal disease in the world. In recent years, IPF has been considered to be an independent risk factor for the development of LC. The incidence of lung cancer is increased in the patients with IPF and the mortality is also significantly increased in the patients inflicted with the two diseases. In this study, we evaluated an animal model of pulmonary fibrosis complicated with LC by implanting LC cells orthotopically into the lungs of mice several days after bleomycin induction of the pulmonary fibrosis in the same mice. In vivo studies with the model showed that exogenous recombinant human thymosin beta 4 (exo-rhTß4) alleviated the impairment of lung function and severity of damage of the alveolar structure by the pulmonary fibrosis and inhibited the proliferation of LC tumor growth. In addition, in vitro studies showed that exo-rhTß4 inhibited the proliferation and migration of A549 and Mlg cells. Furthermore, our results also showed that rhTß4 could effectively inhibit the JAK2-STAT3 signaling pathway and this might exert an anti-IPF-LC effect. The establishment of the IPF-LC animal model will be helpful for the development of drugs for the treatment of IPF-LC. Exogenous rhTß4 can be potentially used for the treatment of IPF and LC.
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Texto completo: 1 Coleções: 01-internacional Temas: Cuidados_paliativos / Geral / Tipos_de_cancer / Pulmao Base de dados: MEDLINE Assunto principal: Timosina / Fibrose Pulmonar Idiopática / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Temas: Cuidados_paliativos / Geral / Tipos_de_cancer / Pulmao Base de dados: MEDLINE Assunto principal: Timosina / Fibrose Pulmonar Idiopática / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China