Design, Synthesis, and Anti-Cancer Evaluation of Novel Cyclic Phosphate Prodrug of Gemcitabine.

Zhang, Liang; Qi, Kangjing; Xu, Jie; Xing, Yan; Wang, Xuejian; Tong, Ling; He, Zengguo; Xu, Wenfang; Li, Xiaoyang; Jiang, Yuqi

Zhang, Liang; Qi, Kangjing; Xu, Jie; Xing, Yan; Wang, Xuejian; Tong, Ling; He, Zengguo; Xu, Wenfang; Li, Xiaoyang; Jiang, Yuqi.

Afiliação

Zhang L; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Qi K; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, P.R. China.
Xu J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Xing Y; Oncology and Immunology Unit, Research Service Division, WuXi AppTec, Nantong 226299, China.
Wang X; School of Computer Science and Engineering, Central South University, Changsha 410083, China.
Tong L; Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong 266071, P.R. China.
He Z; College of Pharmacy, Weifang Medical University, Weifang, Shandong 261053, P.R. China.
Xu W; Oncology and Immunology Unit, Research Service Division, WuXi AppTec, Nantong 226299, China.
Li X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Jiang Y; Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong 266071, P.R. China.

J Med Chem ; 66(6): 4150-4166, 2023 03 23.

Article em En | MEDLINE | ID: mdl-36867101

Assuntos

Neoplasias Pancreáticas; Pró-Fármacos; Masculino; Humanos; Gencitabina; Fosfatos/uso terapêutico; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/patologia; Organofosfatos; Ésteres/uso terapêutico; Linhagem Celular Tumoral

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Pró-Fármacos Limite: Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google