Anorectal Function and Clinical Characteristics Associated with Faecal Incontinence in Patients with Crohn's Disease.
J Crohns Colitis
; 17(8): 1252-1261, 2023 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-36951290
ABSTRACT
BACKGROUND AND AIMS:
Faecal incontinence is an important complaint reported by patients with Crohn's disease [CD] and it is associated with several disease-related mechanisms, including anorectal functional disorders. This study aimed to assess the anorectal function and clinical characteristics to identify parameters associated with faecal incontinence in CD patients.METHODS:
This is a cross-sectional study of 104 patients with CD, aged 18 years or older, from a referral centre between August 2019 and May 2021. Patients responded to a specific questionnaire, and underwent medical record review, proctological examination and anorectal functional assessment with anorectal manometry.RESULTS:
Of the 104 patients, 49% were incontinent. Patients with incontinence had a lower mean resting pressure [43.5 vs 53.1 mmHg; pâ =â 0.038], lower mean squeeze pressure [62.1 vs 94.1 mmHg; pâ =â 0.036] and lower maximum rectal capacity [140 vs 180 mL; pâ <â 0.001]. Faecal incontinence was also associated with disease activity [pâ <â 0.001], loose stools [pâ =â 0.02], perianal disease [pâ =â 0.006], previous anoperineal surgery [pâ =â 0.048] and number of anorectal surgeries [pâ =â 0.036].CONCLUSIONS:
This is the largest reported study describing manometric findings of Crohn's disease patients with and without faecal incontinence. Our results identified an association between faecal incontinence and functional disorders, in addition to clinical features in these patients. Functional assessment with anorectal manometry may help choose the best treatment for faecal incontinence in patients with CD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Doença de Crohn
/
Incontinência Fecal
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Crohns Colitis
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Brasil