Severity of myxomatous mitral valve disease in dogs may be predicted using neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratio.
Am J Vet Res
; 84(6)2023 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-37024099
ABSTRACT
OBJECTIVE:
To investigate the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in dogs with myxomatous mitral valve disease (MMVD). ANIMALS 106 dogs with MMVD and 22 healthy dogs were included in the study. PROCEDURES CBC data were obtained retrospectively, and NLR, MLR, and PLR were compared between dogs with MMVD and healthy dogs. The ratios were also analyzed according to MMVD severity.RESULTS:
NLR and MLR were significantly higher in dogs with MMVD C and D (NLR of 4.99 [3.69-7.27]; MLR of 0.56 [0.36-0.74]) than in healthy dogs (NLR 3.05 [1.82-3.37], P < .001; MLR 0.21 [0.14-0.32], P < .001), MMVD stage B1 (NLR 3.15 [2.15-3.86], P < .001; MLR 0.26 [0.20-0.36], P < .001), and MMVD stage B2 dogs (NLR 3.22 [2.45-3.85], P < .001; MLR 0.30 [0.19-0.37], P < .001). The area under the receiver operating characteristic curves of the NLR and MLR to distinguish dogs with MMVD C and D from those with MMVD B were 0.84 and 0.89, respectively. The optimal cutoff value for NLR was 4.296 (sensitivity, 68%; specificity, 83.95%), and the MLR value was 0.322 (sensitivity, 96%; specificity, 66.67%). NLR and MLR were significantly decreased after treatment in dogs with congestive heart failure (CHF). CLINICAL RELEVANCE NLR and MLR can be used as adjunctive indicators of CHF in dogs.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Doenças do Cão
/
Insuficiência Cardíaca
/
Doenças das Valvas Cardíacas
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Am J Vet Res
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Coréia do Sul