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Pan-cancer analysis reveals IGFL2 as a potential target for cancer prognosis and immunotherapy.
Wang, Yuqi; Yuan, Hongwei; Yue, Genquan; Zhao, Lingyan; Xia, Yuan; Zhang, Nan; Li, Hailing; Liu, Dongyang; Su, Yubo; Wang, Haisheng; Gao, Yumin.
Afiliação
  • Wang Y; School of Public Health, Inner Mongolia Medical University, Hohhot, China.
  • Yuan H; Department of Pathology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
  • Yue G; Department of Urology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
  • Zhao L; School of Public Health, Inner Mongolia Medical University, Hohhot, China.
  • Xia Y; Key Laboratory of Molecular Epidemiology of Chronic Diseases, Inner Mongolia Medical University, Hohhot, China.
  • Zhang N; School of Public Health, Inner Mongolia Medical University, Hohhot, China.
  • Li H; Key Laboratory of Molecular Epidemiology of Chronic Diseases, Inner Mongolia Medical University, Hohhot, China.
  • Liu D; School of Public Health, Inner Mongolia Medical University, Hohhot, China.
  • Su Y; Key Laboratory of Molecular Epidemiology of Chronic Diseases, Inner Mongolia Medical University, Hohhot, China.
  • Wang H; School of Public Health, Inner Mongolia Medical University, Hohhot, China.
  • Gao Y; Key Laboratory of Molecular Epidemiology of Chronic Diseases, Inner Mongolia Medical University, Hohhot, China.
Sci Rep ; 13(1): 6034, 2023 04 13.
Article em En | MEDLINE | ID: mdl-37055418
ABSTRACT
Insulin-like growth factor like family member 2 (IGFL2) is a gene in the IGFL family, located on chromosome 19, whose role in cancer is unclear, and the aim of this study was to investigate the relevance of IGFL2 expression, prognosis, immunity, and mutation in pan-cancer. Obtaining information from The Cancer Genome Atlas and The Genotype-Tissue Expression Project (GTEx) databases for expression analysis and combining with The Gene Expression Profile Interaction Analysis database for prognostic aspects. Analysis of immune cell infiltration by TIMER and CIBERSORT algorithms. Calculation of correlation of immune-related genes with IGFL2 expression and tumor mutational burden and microsatellite instability. Mutations and DNA methylation were analyzed using the cBioPortal database and the UALCAN database, and functional enrichment was performed using Gene set enrichment analysis (GSEA). IGFL2 expression is significantly elevated in tumor tissue and high expression has a worse prognosis in most cancers. In immune correlation analysis, it was associated with most immune cells and immune-related genes. In most cancers, IGFL2 methylation is lower and the group with mutations in IGFL2 has a worse prognosis than the normal group. The GSEA analysis showed that IGFL2 was significantly enriched in signaling and metabolism. IGFL2 may be involved in the development of many types of cancer, influencing the course of cancer with different biological functions. It may also be a biomarker for tumor immunotherapy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Imunoterapia / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Imunoterapia / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China