Elevated serum ß-hydroxybutyrate, a circulating ketone metabolite, accelerates colorectal cancer proliferation and metastasis via ACAT1.

Mao, Tianxiao; Qin, Fujian; Zhang, Mengdi; Li, Jing; Li, Jiankang; Lai, Maode

Mao, Tianxiao; Qin, Fujian; Zhang, Mengdi; Li, Jing; Li, Jiankang; Lai, Maode.

Afiliação

Mao T; State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210000, China.
Qin F; State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210000, China.
Zhang M; State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210000, China.
Li J; The Clinical Metabolomics Center, China Pharmaceutical University, Nanjing, 210000, China.
Li J; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210000, China.
Lai M; Xi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, China. lijiankang-1025@nwpu.edu.cn.

Oncogene ; 42(23): 1889-1899, 2023 06.

Article em En | MEDLINE | ID: mdl-37185457

Assuntos

Neoplasias Colorretais; Cetonas; Animais; Humanos; Ácido 3-Hidroxibutírico/farmacologia; Espectrometria de Massas em Tandem; Neoplasias Colorretais/patologia; Proliferação de Células; Acetil-CoA C-Acetiltransferase/genética; Acetil-CoA C-Acetiltransferase/metabolismo

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Cetonas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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