P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in Mice.

F Martins, Margarida L; Loos, Nancy H C; El Yattouti, Malika; Offeringa, Lianda; Heydari, Paniz; Hillebrand, Michel J X; Lebre, Maria C; Beijnen, Jos H; Schinkel, Alfred H

F Martins, Margarida L; Loos, Nancy H C; El Yattouti, Malika; Offeringa, Lianda; Heydari, Paniz; Hillebrand, Michel J X; Lebre, Maria C; Beijnen, Jos H; Schinkel, Alfred H.

Afiliação

F Martins ML; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
Loos NHC; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
El Yattouti M; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Offeringa L; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Heydari P; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
Hillebrand MJX; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Lebre MC; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beijnen JH; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
Schinkel AH; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

Pharm Res ; 40(8): 1885-1899, 2023 Aug.

Article em En | MEDLINE | ID: mdl-37344602

Assuntos

Heroína; Morfina; Camundongos; Animais; Heroína/metabolismo; Heroína/farmacologia; Morfina/metabolismo; Analgésicos Opioides/metabolismo; Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo; Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/metabolismo; Proteínas de Neoplasias/metabolismo; Encéfalo/metabolismo; Derivados da Morfina/metabolismo; Derivados da Morfina/farmacologia; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo; Camundongos Knockout

Palavras-chave

6-monoacetylmorphine/6-MAM; BCRP/ABCG2; P-glycoprotein/ABCB1; heroin/diacetylmorphine; morphine

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Heroína / Morfina Limite: Animals Idioma: En Revista: Pharm Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

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