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Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells.
Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; Di Bello, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello.
Afiliação
  • Zwergel C; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Aventaggiato M; Department of Experimental Medicine, "Department of Excellence 2023-2027", Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
  • Garbo S; Department of Molecular Medicine, "Department of Excellence 2023-2027", Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
  • Di Bello E; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Fassari B; Dompé Farmaceutici S.p.A, Via Campo di Pile snc, 67100 L'Aquila, Italy.
  • Noce B; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Castiello C; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Lambona C; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Barreca F; Department of Experimental Medicine, "Department of Excellence 2023-2027", Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
  • Rotili D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Fioravanti R; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Schmalz T; Dept. Organic Chemistry, University of Bayreuth, Universitätsstr. 30, 95447 Bayreuth, Germany.
  • Weyand M; Dept. Biochemistry, University of Bayreuth, Universitätsstr. 30, 95447 Bayreuth, Germany.
  • Niedermeier A; Dept. Biochemistry, University of Bayreuth, Universitätsstr. 30, 95447 Bayreuth, Germany.
  • Tripodi M; Department of Molecular Medicine, "Department of Excellence 2023-2027", Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
  • Colotti G; Institute of Molecular Biology and Pathology, Italian National Research Council, Piazzale A.Moro 5, 20, 00185 Rome, Italy.
  • Steegborn C; Dept. Organic Chemistry, University of Bayreuth, Universitätsstr. 30, 95447 Bayreuth, Germany.
  • Battistelli C; Department of Molecular Medicine, "Department of Excellence 2023-2027", Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
  • Tafani M; Department of Experimental Medicine, "Department of Excellence 2023-2027", Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
  • Valente S; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
J Med Chem ; 66(14): 9622-9641, 2023 07 27.
Article em En | MEDLINE | ID: mdl-37439550
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Sirtuína 3 / Neoplasias Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Sirtuína 3 / Neoplasias Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália