iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway.

Guo, Yongzheng; You, Yuehua; Shang, Fei-Fei; Wang, Xiaowen; Huang, Bi; Zhao, Boying; Lv, Dingyi; Yang, Shenglan; Xie, Ming; Kong, Lingwen; Du, Dingyuan; Luo, Suxin; Tian, Xin; Xia, Yong

Guo, Yongzheng; You, Yuehua; Shang, Fei-Fei; Wang, Xiaowen; Huang, Bi; Zhao, Boying; Lv, Dingyi; Yang, Shenglan; Xie, Ming; Kong, Lingwen; Du, Dingyuan; Luo, Suxin; Tian, Xin; Xia, Yong.

Afiliação

Guo Y; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
You Y; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Shang FF; Institute of Life Science, Chongqing Medical University, Chongqing 400016, China.
Wang X; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Huang B; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhao B; Department of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Lv D; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yang S; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xie M; Department of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Kong L; Department of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Du D; Department of Cardiothoracic Surgery, Chongqing University Central Hospital, Chongqing 400014, China.
Luo S; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Tian X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing 400016, China.
Xia Y; Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Theranostics ; 13(12): 4229-4246, 2023.

Article em En | MEDLINE | ID: mdl-37554263

Assuntos

DNA Mitocondrial; Cardiopatias; Óxido Nítrico Sintase Tipo II; Animais; Humanos; Camundongos; Citosol/metabolismo; DNA Mitocondrial/genética; DNA Mitocondrial/metabolismo; Cardiopatias/metabolismo; Inflamação/metabolismo; Camundongos Knockout; Mitocôndrias/metabolismo; Miócitos Cardíacos/metabolismo; Nucleotidiltransferases/genética; Nucleotidiltransferases/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo

Palavras-chave

Cardiac dysfunction; Sterile inflammation; cGAS; iNOS; mtDNA

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Óxido Nítrico Sintase Tipo II / Cardiopatias Limite: Animals / Humans Idioma: En Revista: Theranostics Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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