Metabolic syndrome prevalence and impact on outcomes in patients with chronic graft-versus-host disease.
Bone Marrow Transplant
; 58(12): 1377-1383, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37684526
ABSTRACT
Patients with chronic graft-versus-host disease (cGVHD) are at heightened risk for components of metabolic syndrome (MetS), yet the prevalence and impact of MetS in the cGVHD patient population remain unknown. Adult patients (n = 229) with cGVHD enrolled in the cross-sectional NIH cGVHD Natural History Study (NCT00092235) were evaluated for MetS at enrollment and for variables associated with MetS. A majority (54.1%, 124/229) of the cohort met the diagnostic criteria for MetS. Patients with higher body mass index and lower performance status scores were more likely to have MetS (P < 0.0001; P = 0.026; respectively). Higher circulating erythrocyte sedimentation rate, C-reactive protein, and creatinine concentrations, along with lower estimated glomerular filtration rate, were associated with MetS (P < 0.001; P < 0.004; P = 0.02; P = 0.002; respectively). Patients with MetS compared to patients without MetS had no statistical differences in survival or NRM (5-year OS 64% [95% CI 54.8-71.8%] vs. 75.1% [95% CI 65.6-82.3%]; respectively; overall P = 0.20; 5-year NRM 21.7% [95% CI 13.6-30.9%] vs. 10.1% [95% CI 4.4-18.7%]; respectively; overall P = 0.12). Additionally, there was no difference in cGVHD severity between the two groups. Given the high prevalence of MetS in this cohort, clinicians should screen for its presence before it develops into comorbidities that complicate the course of cGVHD treatment.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco Hematopoéticas
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Síndrome Metabólica
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Síndrome de Bronquiolite Obliterante
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Doença Enxerto-Hospedeiro
Tipo de estudo:
Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Humans
Idioma:
En
Revista:
Bone Marrow Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos