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The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring.
Batool, Syeda Maheen; Yekula, Anudeep; Khanna, Prerna; Hsia, Tiffaney; Gamblin, Austin S; Ekanayake, Emil; Escobedo, Ana K; You, Dong Gil; Castro, Cesar M; Im, Hyungsoon; Kilic, Tugba; Garlin, Michelle Andrea; Skog, Johan; Dinulescu, Daniela M; Dudley, Jonathan; Agrawal, Nishant; Cheng, Jordan; Abtin, Fereidoun; Aberle, Denise R; Chia, David; Elashoff, David; Grognan, Tristan; Krysan, Kostyantyn; Oh, Scott S; Strom, Charles; Tu, Michael; Wei, Fang; Xian, Rena R; Skates, Steven J; Zhang, David Y; Trinh, Thi; Watson, Mark; Aft, Rebecca; Rawal, Siddarth; Agarwal, Ashutosh; Kesmodel, Susan B; Yang, Changhuei; Shen, Cheng; Hochberg, Fred H; Wong, David T W; Patel, Abhijit A; Papadopoulos, Nickolas; Bettegowda, Chetan; Cote, Richard J; Srivastava, Sudhir; Lee, Hakho; Carter, Bob S; Balaj, Leonora.
Afiliação
  • Batool SM; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Yekula A; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Khanna P; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Hsia T; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Gamblin AS; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Ekanayake E; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Escobedo AK; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • You DG; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Castro CM; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Im H; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Kilic T; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Garlin MA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Skog J; Exosome Diagnostics Inc., Waltham, MA, USA.
  • Dinulescu DM; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Dudley J; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Agrawal N; University of Chicago School of Medicine, Chicago, IL, USA.
  • Cheng J; University of California Los Angeles, Los Angeles, CA, USA.
  • Abtin F; University of California Los Angeles, Los Angeles, CA, USA.
  • Aberle DR; University of California Los Angeles, Los Angeles, CA, USA.
  • Chia D; University of California Los Angeles, Los Angeles, CA, USA.
  • Elashoff D; University of California Los Angeles, Los Angeles, CA, USA.
  • Grognan T; University of California Los Angeles, Los Angeles, CA, USA.
  • Krysan K; University of California Los Angeles, Los Angeles, CA, USA.
  • Oh SS; University of California Los Angeles, Los Angeles, CA, USA.
  • Strom C; University of California Los Angeles, Los Angeles, CA, USA.
  • Tu M; Liquid Diagnostics LLC., Los Angeles, CA, USA.
  • Wei F; University of California Los Angeles, Los Angeles, CA, USA.
  • Xian RR; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Skates SJ; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Zhang DY; Rice University, Houston, TX, USA.
  • Trinh T; Yale University School of Medicine, New Haven, CT, USA.
  • Watson M; Washington University School of Medicine, St. Louis, MO, USA.
  • Aft R; Washington University School of Medicine, St. Louis, MO, USA.
  • Rawal S; Washington University School of Medicine, St. Louis, MO, USA; Circulogix Inc., St. Louis, MO, USA.
  • Agarwal A; University of Miami, Miami, FL, USA.
  • Kesmodel SB; University of Miami, Miami, FL, USA.
  • Yang C; California Institute of Technology, Pasadena, CA, USA.
  • Shen C; California Institute of Technology, Pasadena, CA, USA.
  • Hochberg FH; Scintillon Institute, La Jolla, CA, USA.
  • Wong DTW; University of California Los Angeles, Los Angeles, CA, USA.
  • Patel AA; Yale University School of Medicine, New Haven, CT, USA.
  • Papadopoulos N; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Bettegowda C; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Cote RJ; Washington University School of Medicine, St. Louis, MO, USA; Circulogix Inc., St. Louis, MO, USA.
  • Srivastava S; Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
  • Lee H; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Carter BS; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Balaj L; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: balaj.leonora@mgh.harvard.edu.
Cell Rep Med ; 4(10): 101198, 2023 10 17.
Article em En | MEDLINE | ID: mdl-37716353
ABSTRACT
The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strategies include detection and monitoring of circulating tumor cells, cell-free DNA, and extracellular vesicles. In this review, we address the current understanding and the role of existing liquid-biopsy-based modalities in cancer diagnostics and monitoring. We specifically focus on the technical and clinical challenges associated with liquid biopsy and biomarker development being addressed by the Liquid Biopsy Consortium, established through the National Cancer Institute. The Liquid Biopsy Consortium has developed new methods/assays and validated existing methods/technologies to capture and characterize tumor-derived circulating cargo, as well as addressed existing challenges and provided recommendations for advancing biomarker assays.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Ácidos Nucleicos Livres / Células Neoplásicas Circulantes Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Revista: Cell Rep Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Ácidos Nucleicos Livres / Células Neoplásicas Circulantes Tipo de estudo: Diagnostic_studies / Guideline Limite: Humans Idioma: En Revista: Cell Rep Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos