CD40 agonism improves anti-tumor T cell priming induced by the combination of radiation therapy plus CTLA4 inhibition and enhances tumor response.
Oncoimmunology
; 12(1): 2258011, 2023.
Article
em En
| MEDLINE
| ID: mdl-37727740
ABSTRACT
Radiation therapy (RT) combined with CTLA4 blockers converts immunosuppressed (cold) mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have recently shown that targeting the myeloid compartment to improve dendritic cell activation is required for most TNBC-bearing mice to achieve superior therapeutic responses to RT plus CTLA4 inhibitors.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Prevencao_e_fatores_de_risco
/
Agentes_cancerigenos
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Neoplasias de Mama Triplo Negativas
/
Inibidores de Checkpoint Imunológico
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Oncoimmunology
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos