Estrogen receptor alpha-mediated mitochondrial damage in intrahepatic bile duct epithelial cells leading to the pathogenesis of primary biliary cholangitis.

Liang, Mengting; Ye, Siwen; Jing, Rubin; Zhu, Bukun; Yuan, Wenjie; Chu, Xi; Li, Ying; Zhang, Wei

Liang, Mengting; Ye, Siwen; Jing, Rubin; Zhu, Bukun; Yuan, Wenjie; Chu, Xi; Li, Ying; Zhang, Wei.

Afiliação

Liang M; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ye S; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jing R; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhu B; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuan W; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chu X; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li Y; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhang W; Department of Infection, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Environ Toxicol ; 38(12): 2803-2818, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37740728

Assuntos

Células Epiteliais; Receptor alfa de Estrogênio; Cirrose Hepática Biliar; Mitocôndrias; Humanos; Cirrose Hepática Biliar/patologia; Ductos Biliares Intra-Hepáticos/citologia; Células Epiteliais/patologia; Mitocôndrias/patologia; Estresse Oxidativo; Estudos de Casos e Controles; Receptor alfa de Estrogênio/metabolismo; Estrogênios/metabolismo; Apoptose; Feminino; Pessoa de Meia-Idade; Sobrevivência Celular; Estradiol/farmacologia; Proteínas Reguladoras de Apoptose/metabolismo

Palavras-chave

apoptosis; estrogen receptor alpha; intrahepatic bile duct epithelial cells; mitochondrial damage; primary biliary cholangitis (PBC)

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Receptor alfa de Estrogênio / Células Epiteliais / Cirrose Hepática Biliar / Mitocôndrias Tipo de estudo: Etiology_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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