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Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single-arm clinical trial.
Parvizi, Mohammad Mahdi; Saki, Nasrin; Samimi, Soodabeh; Radanfer, Roya; Shahrizi, Mohammad Miaad; Zarshenas, Mohammad Mehdi.
Afiliação
  • Parvizi MM; Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Saki N; Department of Dermatology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Samimi S; Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Radanfer R; Department of Dermatology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Shahrizi MM; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Zarshenas MM; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
J Cosmet Dermatol ; 23(3): 911-917, 2024 Mar.
Article em En | MEDLINE | ID: mdl-37927123
ABSTRACT

INTRODUCTION:

Infraorbital hyperpigmentation represents one of the most prevalent conditions in cosmetic dermatology. To treat this condition, many patients prefer natural remedies. This study explored the efficacy of topical castor oil cream in treating patients with infraorbital hyperpigmentation.

METHODS:

We conducted an exploratory single-arm clinical trial at the Shahid Faghihi Dermatology Clinic and Molecular Dermatology Research Center of Shiraz University of Medical Sciences, Shiraz, Iran, during 2021-2022. Using the convenience sampling method, we enrolled 25 patients with infraorbital hyperpigmentation. We instructed the patients to apply topical castor oil cream twice daily for 2 months. The darkness, melanin, and erythema levels were evaluated by VisioFace® 1000 D and SkinColorCatch® devices. We used a visual analog scale to assess skin laxity, wrinkles, and patient satisfaction. Data analysis was done with Stata version 14.2.

RESULTS:

The data of 22 patients with a mean age of 40.92 ± 7.33 years were analyzed. The VisioFace® scores decreased significantly by the end of the study [right eyes mean difference (MD) -5.63 (95% CI -7.12 to -4.15), p < 0.001; left eyes MD -5.91 (95% CI -7.46 to -4.36), p < 0.001]. Moreover, castor oil cream significantly reduced the melanin level, wrinkles, and skin laxity in the infraorbital region (p < 0.05).

CONCLUSIONS:

Castor oil cream seems to be an effective alternative for treating infraorbital hyperpigmentation. Randomized clinical trials are needed to confirm our findings.
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Texto completo: 1 Coleções: 01-internacional Temas: Agentes_cancerigenos Base de dados: MEDLINE Assunto principal: Óleo de Rícino / Hiperpigmentação Limite: Adult / Humans / Middle aged Idioma: En Revista: J Cosmet Dermatol Assunto da revista: DERMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Irã

Texto completo: 1 Coleções: 01-internacional Temas: Agentes_cancerigenos Base de dados: MEDLINE Assunto principal: Óleo de Rícino / Hiperpigmentação Limite: Adult / Humans / Middle aged Idioma: En Revista: J Cosmet Dermatol Assunto da revista: DERMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Irã