Targeting Prolyl 4-Hydroxylase Subunit Beta (P4HB) in Cancer: New Roads to Travel.

Feng, Dechao; Wang, Jie; Li, Dengxiong; Wu, Ruicheng; Tuo, Zhouting; Yu, Qingxin; Ye, Luxia; Miyamoto, Akira; Yoo, Koo Han; Wang, Cheng; Cheng, Yuanzhi; Ye, Xing; Zhang, Chi; Wei, Wuran

Feng, Dechao; Wang, Jie; Li, Dengxiong; Wu, Ruicheng; Tuo, Zhouting; Yu, Qingxin; Ye, Luxia; Miyamoto, Akira; Yoo, Koo Han; Wang, Cheng; Cheng, Yuanzhi; Ye, Xing; Zhang, Chi; Wei, Wuran.

Afiliação

Feng D; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Wang J; Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Li D; Chengdu Basebio Company, China.
Wu R; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Tuo Z; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Yu Q; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Ye L; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Miyamoto A; Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang, China.
Yoo KH; Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
Wang C; Department of Rehabilitation, West Kyushu University, Japan.
Cheng Y; Department of Urology, Kyung Hee University, South Korea.
Ye X; Chengdu Basebio Company, China.
Zhang C; Chengdu Basebio Company, China.
Wei W; Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Aging Dis ; 2023 Nov 26.

Article em En | MEDLINE | ID: mdl-38029391

ABSTRACT

ABSTRACT

Prolyl 4-hydroxylase subunit beta (P4HB) can catalyze the formation, breakage and rearrangement of disulfide bonds through two thioredoxin domains, which is important for the maintenance of oxidizing environment in endoplasmic reticulum. Recently, P4HB has been demonstrated its oncogenic role of tumorigenesis and development in cancers. Therefore, we comprehensively deciphered P4HB in human cancer from various aspects, including pan-cancer analysis and narrative summary. We also provided some possible interacted molecules and the top 10 predicted drugs targeting P4HB to contribute to future research. We proposed that P4HB was a potential target and brought new therapeutic opportunities for cancer patients.

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Idioma: En Revista: Aging Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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