Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators.

Shaw, Simon J; Goff, Dane A; Boralsky, Luke A; Singh, Rajinder; Sweeny, David J; Park, Gary; Sun, Tian-Qiang; Jenkins, Yonchu; Markovtsov, Vadim; Issakani, Sarkiz D; Payan, Donald G; Hitoshi, Yasumichi

Shaw, Simon J; Goff, Dane A; Boralsky, Luke A; Singh, Rajinder; Sweeny, David J; Park, Gary; Sun, Tian-Qiang; Jenkins, Yonchu; Markovtsov, Vadim; Issakani, Sarkiz D; Payan, Donald G; Hitoshi, Yasumichi.

Afiliação

Shaw SJ; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Goff DA; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Boralsky LA; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Singh R; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Sweeny DJ; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Park G; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Sun TQ; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Jenkins Y; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Markovtsov V; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Issakani SD; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Payan DG; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.
Hitoshi Y; Rigel Pharmaceuticals, Inc., 611 Gateway Boulevard, Suite 900, South San Francisco, California 94080, United States.

J Med Chem ; 66(24): 17086-17104, 2023 12 28.

Article em En | MEDLINE | ID: mdl-38079537

Assuntos

Diabetes Mellitus Tipo 2; Camundongos; Ratos; Animais; Proteínas Quinases Ativadas por AMP; Diamida; Glucose; Piridinas/farmacologia; Piperidinas; Amidas

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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