Regenerating murine CD8+ lung tissue resident memory T cells after targeted radiation exposure.
J Exp Med
; 221(3)2024 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-38363548
ABSTRACT
Radiation exposure occurs during medical procedures, nuclear accidents, or spaceflight, making effective medical countermeasures a public health priority. Naïve T cells are highly sensitive to radiation-induced depletion, although their numbers recover with time. Circulating memory CD8+ T cells are also depleted by radiation; however, their numbers do not recover. Critically, the impact of radiation exposure on tissue-resident memory T cells (TRM) remains unknown. Here, we found that sublethal thorax-targeted radiation resulted in the rapid and prolonged numerical decline of influenza A virus (IAV)-specific lung TRM in mice, but no decline in antigen-matched circulating memory T cells. Prolonged loss of lung TRM was associated with decreased heterosubtypic immunity. Importantly, boosting with IAV-epitope expressing pathogens that replicate in the lungs or peripheral tissues or with a peripherally administered mRNA vaccine regenerated lung TRM that was derived largely from circulating memory CD8+ T cells. Designing effective vaccination strategies to regenerate TRM will be important in combating the immunological effects of radiation exposure.
Texto completo:
1
Coleções:
01-internacional
Temas:
Agentes_cancerigenos
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Infecções por Orthomyxoviridae
/
Exposição à Radiação
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
/
J. exp. med
/
Journal of experimental medicine
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos