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Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients.
Koo, Bon Jin; Huh, Hyuk; Ye, Byung Min; Kim, Yunmi; Choi, Byung Hyun; Lee, Hyun Jeong; Kang, Mi Seon; Lee, Dong Won; Lee, Soo Bong; Kim, Yeong Hoon; Kim, Il Young; Kim, Taehee; Kim, Seo Rin.
Afiliação
  • Koo BJ; Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, South Korea.
  • Huh H; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
  • Ye BM; Department of Internal Medicine-Nephrology, Inje University Busan Paik Hospital, Busan, South Korea.
  • Kim Y; Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, South Korea.
  • Choi BH; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
  • Lee HJ; Department of Internal Medicine-Nephrology, Inje University Busan Paik Hospital, Busan, South Korea.
  • Kang MS; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
  • Lee DW; Department of Surgery, Pusan National University School of Medicine, Yangsan, South Korea.
  • Lee SB; Department of Pathology, Pusan National University School of Medicine, Yangsan, South Korea.
  • Kim YH; Department of Pathology, Inje University Busan Paik Hospital, Busan, South Korea.
  • Kim IY; Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, South Korea.
  • Kim T; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
  • Kim SR; Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, South Korea.
Sci Rep ; 14(1): 4002, 2024 02 18.
Article em En | MEDLINE | ID: mdl-38369626
ABSTRACT
A for-cause biopsy is performed to diagnose the cause of allograft dysfunction in kidney transplantation. We occasionally encounter ambiguous biopsy results in symptomatic kidney transplant recipients. Yet, the allograft survival outcome in symptomatic recipients with nonspecific allograft biopsy findings remains unclear. The purpose of this study was to analyze the impact of nonspecific for-cause biopsy findings in symptomatic kidney transplant recipients. We retrospectively collected records from 773 kidney transplant recipients between January 2008 and October 2021. The characteristics of transplant recipients with nonspecific findings in the first for-cause biopsy were analyzed. Nonspecific allograft biopsy findings were defined as other biopsy findings excluding rejection, borderline rejection, calcineurin inhibitor toxicity, infection, glomerulonephritis, and diabetic nephropathy. The graft outcome was compared between recipients who had never undergone a for-cause biopsy and those who had a first for-cause biopsy with nonspecific findings. The graft survival in recipients with nonspecific for-cause biopsy findings was comparable to that in recipients who did not require the for-cause biopsy before and after propensity score matching. Even in symptomatic kidney transplant recipients, nonspecific allograft biopsy findings might not be a poor prognostic factor for allograft survival compared to recipients who did not require the for-cause biopsy.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Transplante de Rim Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Coréia do Sul

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Transplante de Rim Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Coréia do Sul