Review of Animal Models of Colorectal Cancer in Different Carcinogenesis Pathways.
Dig Dis Sci
; 69(5): 1583-1592, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38526618
ABSTRACT
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with increasing morbidity and mortality. Exploring the factors affecting colorectal carcinogenesis and controlling its occurrence at its root is as important as studying post-cancer treatment and management. Establishing ideal animal models of CRC is crucial, which can occur through various pathways, such as adenoma-carcinoma sequence, inflammation-induced carcinogenesis, serrated polyp pathway and de-novo pathway. This article aims to categorize the existing well-established CRC animal models based on different carcinogenesis pathways, and to describe their mechanisms, methods, advantages and limitations using domestic and international literature sources. This will provide suggestions for the selection of animal models in early-stage CRC research.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
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Colon_e_reto
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
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Modelos Animais de Doenças
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Carcinogênese
Limite:
Animals
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Humans
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China